From: Subject: Prana Biotechnology Date: Tue, 8 Jul 2008 12:13:14 +1000 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C8E0F3.FF7BD740" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C8E0F3.FF7BD740 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.pranabio.com/company_profile/press_releases_item.asp?id=161 Prana Biotechnology
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8 July 2008

Prana Co-Founding Scientist Professor Rudolph Tanzi, = Addressed=20 U.S. Senate Special Committee on Aging
MELBOURNE, = Australia=20 =96 July 8, 2008 =96 Rudolph E. Tanzi, Ph.D., Co-Founding = Scientist of=20 Prana Biotechnology Limited (NASDAQ: PRAN / ASX: PBT), a=20 biopharmaceutical company focused on the research and = development of=20 treatments for neurodegenerative disorders, was invited this = past=20 May to testify in front of the U.S. Senate Special Committee = on=20 Aging on the Future of Alzheimer's: Breakthroughs and = Challenges.=20 The hearing, lead by Senator Herb Kohl (D-WI) and Senator = Gordon H.=20 Smith (R-OR), discussed Alzheimer=92s Disease as a growing = crisis and=20 how the United States can accelerate its efforts against the = disease. Additional participants included Sandra Day = O'Connor,=20 Former Supreme Court Justice, Member of the Alzheimer's = Study Group,=20 Newt Gingrich, Former Speaker of the House of = Representatives,=20 Member of the Alzheimer's Study Group, Charles Jackson, = Alzheimer's=20 patient and Suzanne Carabone, Alzheimer's patient caregiver. =

The recent failed clinical studies of what were=20 once-promising Alzheimer=92s drugs have now attracted much = attention=20 to Prana and the future of therapeutic treatments to = Alzheimer=92s=20 disease. In response Dr. Tanzi, an internationally = recognized=20 authority on Alzheimer=92s disease who has co-discovered = three of the=20 four known genes that cause Alzheimer's disease, presented=20 information to the U.S. Senate on the differing = Abeta-targeted=20 therapeutic approaches, and commented upon the ongoing = clinical=20 trials in Alzheimer=92s disease.

Key material from = the=20 testimonial included:

=95 Future prospects for = immunotherapy=20 and gamma-secretase therapeutic approaches;
=95 = Approaches to=20 targeting and regulating Abeta production; and,
=95 = Recent=20 developments regarding drugs aimed at treating and = preventing=20 Alzheimer=92s disease.

Prana=92s theories concerning = the=20 interaction between metals and the protein Abeta in the = brain are=20 the basis of the company=92s treatments for Alzheimer's and = other=20 neurodegenerative diseases. Prana=92s proprietary lead = compound, PBT2,=20 recently concluded a Phase IIa trial in early Alzheimer=92s = disease,=20 which demonstrated safety and tolerability, and significant=20 reductions in Abeta 42 and improvement in Executive Function = performance in cognitive tests. Prana will be presenting = this data=20 at the International Conference on Alzheimer=92s Disease = (ICAD) in=20 July.

Dr Tanzi stated, =93Unlike other approaches, = Prana=92s=20 PBT2 appears to neutralize the neurotoxicity of Abeta and=20 facilitates it's clearance from the brain. Prana=92s latest = clinical=20 trial results were highly encouraging, by significantly = lowering=20 Abeta 42 in the cerebrospinal fluid, and improving cognition = in the=20 executive function of patients over a 12-week period. I = testified to=20 the U.S. Senate that therapies targeted against the amyloid = beta=20 protein offer the best chance at slowing down the = progression of=20 Alzheimer's disease. It is my strong belief that PBT2 is = among the=20 very best therapies available for achieving this=20 goal."


About Dr. Rudolph Tanzi
Dr. Rudolph = Tanzi is a=20 Professor of Neurology (and Neuroscience) at Harvard = University, and=20 serves as the Director of the Genetics and Aging Research = Unit=20 consisting of eight laboratories in the MassGeneral = Institute for=20 Neurodegenerative Diseases at MGH. Since 1982, Dr. Tanzi has = focused=20 his studies on Alzheimer's disease (AD). He isolated the = first=20 familial Alzheimer's disease (FAD) gene, known as the = amyloid=20 β-protein (A4) precursor (APP) in 1987, and another in = 1995, called=20 presenilin 2. Dr. Tanzi is also a co-founder of the =93Metal = hypothesis of Alzheimer=92s disease=94. His laboratory first = discovered=20 that the metals zinc and copper are necessary for the = formation of=20 neurotoxic assemblies of the AD-associated peptide, Aβ, = the main=20 component of β-amyloid deposits in brains of AD = patients. These=20 studies have led to ongoing clinical trials for treating and = preventing AD by targeting Aβmetal interactions. =

Dr. Tanzi=20 has co-authored over 320 research articles and reviews, = including=20 three of the top ten most cited papers in AD research over = the last=20 decade over which time he was the 5th most cited scientist = in the=20 field of AD research. He is also a co-author of a popular = trade book=20 on Alzheimer=92s disease entitled =93Decoding Darkness: The = Search for=20 the Genetic Causes of Alzheimer=92s Disease=94. Dr. Tanzi = has received=20 several awards for his work including the two highest awards = for=20 Alzheimer=92s disease research: The Metropolitan Life = Foundation Award=20 and The Potamkin Prize.


About Prana = Biotechnology=20 Limited
Prana Biotechnology was established to = commercialize=20 research into Alzheimer's disease and other major = age-related=20 neurodegenerative disorders. The company was incorporated in = 1997=20 and listed on the Australian Stock Exchange in March 2000 = and listed=20 on NASDAQ in September 2002. Researchers at prominent = international=20 institutions including The University of Melbourne, The = Mental=20 Health Research Institute (Melbourne) and Massachusetts = General=20 Hospital, a teaching hospital of Harvard Medical School, = contributed=20 to the discovery of Prana=92s technology.

For = further=20 information, please visit our web site at=20 www.pranabio.com.


Forward Looking Statements =
This=20 press release contains "forward-looking statements" within = the=20 meaning of section 27A of the Securities Act of 1933 and = section 21E=20 of the Securities Exchange Act of 1934. The Company has = tried to=20 identify such forward-looking statements by use of such = words as=20 "expects," "intends," "hopes," "anticipates," "believes," = "could,"=20 "may," "evidences" and "estimates," and other similar = expressions,=20 but these words are not the exclusive means of identifying = such=20 statements. Such statements include, but are not limited to = any=20 statements relating to the Company's drug development = program,=20 including, but not limited to the initiation, progress and = outcomes=20 of clinical trials of the Company's drug development = program,=20 including, but not limited to, PBT2, and any other = statements that=20 are not historical facts. Such statements involve risks and=20 uncertainties, including, but not limited to, those risks = and=20 uncertainties relating to the difficulties or delays in = financing,=20 development, testing, regulatory approval, production and = marketing=20 of the Company=92s drug components, including, but not = limited to,=20 PBT2, the ability of the Company to procure additional = future=20 sources of financing, unexpected adverse side effects or = inadequate=20 therapeutic efficacy of the Company's drug compounds, = including, but=20 not limited to, PBT2, that could slow or prevent products = coming to=20 market, the uncertainty of patent protection for the = Company's=20 intellectual property or trade secrets, including, but not = limited=20 to, the intellectual property relating to PBT2, and other = risks=20 detailed from time to time in the filings the Company makes = with=20 Securities and Exchange Commission including its annual = reports on=20 From 20-F and its reports on Form 6-K. Such statements are = based on=20 management=92s current expectations, but actual results may = differ=20 materially due to various factions including those risks and = uncertainties mentioned or referred to in this press = release.=20 Accordingly, you should not rely on those forward-looking = statements=20 as a prediction of actual future results. =

Contacts:
Prana=20 Biotechnology Ltd
+61 3 9349=20 4906


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